NAD+
NAD+ (nicotinamide adenine dinucleotide) is a coenzyme found in every living cell. It is involved in energy production and in processes related to DNA repair. In skincare it appears as a conditioning ingredient, listed in INCI as Nicotinamide Adenine Dinucleotide.
It suits you if you are curious about NAD+ and want to try it in a simple step of your routine, knowing that its effect on the skin is still being researched.
What the evidence shows – and what it does not
NAD+ is an essential coenzyme in cellular metabolism and also participates in processes related to DNA repair. Its availability and metabolism are associated with cellular ageing, but this does not establish the effectiveness of NAD+ in skincare. There is currently insufficient high-quality clinical evidence for topically applied cosmetic products to reliably promise specific rejuvenating effects. Findings from supplement studies or laboratory models cannot be directly applied to them.
The NAD+ molecule (about 660 Da) is also larger than the molecules that usually pass easily through intact skin. Brands therefore often list it in liposomes. At VIONE we treat it as an additional ingredient, not a reason for choosing a product.
NAD+ and niacinamide
Niacinamide (vitamin B3) is one of the building blocks cells use to make NAD+. Unlike NAD+, niacinamide is well researched in skincare. If you choose by what is proven, look mainly at niacinamide and the other ingredients in the product.
How to use NAD+ in your routine
NAD+ has no special rules for combining. A toner with NAD+ goes on straight after cleansing, before serum and moisturiser. If NAD+ is part of a product with a retinoid, follow the rules for the retinoid: evenings, gradually and SPF in the morning.
What to watch out for
Do not confuse NAD+ in skincare with food supplements or NAD+ infusions. These are entirely different ways of use, and their results cannot be applied to skincare.
NAD+ products at VIONE
- Eqqualberry NAD+ Peptide Boosting Toner – a hydrating toner with niacinamide, urea, panthenol and hyaluronic acid for tired, maturing skin; NAD+ in liposomal form according to the brand. Fragrance-free.
- K-SECRET Seoul 1988 Retinal Glow Eye Patch – under-eye patches with retinal, with NAD+ as an additional ingredient. For evening use.
Frequently asked questions
Does NAD+ in skincare work like NAD+ supplements?
That cannot be claimed. Supplements are taken by mouth, and studies on them do not concern skincare. For NAD+ applied to the skin, there is not yet enough high-quality clinical evidence.
You will find more care for tired-looking skin in Toners and essences and Mature skin 35+. The peptides that complement the NAD+ toner are described in our glossary entry on peptides.